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货号： bs-8299R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8299R-AF488
- 英文名称
- Anti-TXNRD1/AF488
- 中文名称
- AF488标记的硫氧环蛋白还原酶1抗体
- 别 名
- cytoplasmic; Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; Gene associated with retinoid IFN induced mortality 12 protein; GRIM 12; GRIM-12; GRIM12; KDRF; KM 102 derived reductase like factor; KM-102-derived reductase-like factor; MGC9145; Oxidoreductase; Thioredoxin reductase 1; Thioredoxin reductase 1 cytoplasmic; Thioredoxin reductase GRIM 12 antibodyThioredoxin reductase TR1; TR 1; TR; TR1; TRXR 1; TRXR1; TRXR1_HUMAN; TXNR; TXNRD 1; Txnrd1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 71kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TXNRD1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Subunit:
Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
Subcellular Location:
Cytoplasm. Isoform 4: Cytoplasm. Nucleus. Isoform 5: Cytoplasm.
Tissue Specificity:
Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
Post-translational modifications:
The N-terminus of isoform 5 is blocked.
ISGylated (Probable).
Similarity:
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Contains 1 glutaredoxin domain.
Database links:Entrez Gene: 7296Human
Entrez Gene: 50493Mouse
Entrez Gene: 58819Rat
Omim: 601112Human
SwissProt: O62768Cow
SwissProt: Q16881Human
SwissProt: Q9JMH6Mouse
SwissProt: O89049Rat
Unigene: 210155Mouse
Unigene: 471159Mouse
Unigene: 67581Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.