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货号： bs-6942R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6942R-AF488
- 英文名称
- Anti-POMC/AF488
- 中文名称
- AF488标记的阿黑皮素原抗体
- 别 名
- ACTH; Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Alpha MSH; Alpha-MSH; Beta Endorphin; Beta Lipotropin; Beta LPH; Beta Melanocyte Stimulating Hormone; Beta MSH; Beta-LPH; Beta-MSH; CLIP; COLI_HUMAN; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin; Corticotropin lipotropin precursor; Corticotropin-lipotropin; Gamma MSH; Gamma-LPH; Gamma-MSH; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Melanotropin; Melanotropin beta; Melanotropin gamma; Met Enkephalin; Met-enkephalin; MSH; NPP; POC; POMC; pro ACTH endorphin; Pro opiomelanocortin; Proopiomelanocortin; Proopiomelanocortin preproprotein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 内分泌病
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 29kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human POMC
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Function:
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.
Subcellular Location:
Secreted.
Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.
Post-translational modifications:
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
DISEASE:
Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
Similarity:
Belongs to the POMC family.
Database links:Entrez Gene: 5443Human
Entrez Gene: 18976Mouse
Entrez Gene: 24664Rat
Omim: 176830Human
SwissProt: P01190Cow
SwissProt: P01189Human
SwissProt: P01193Mouse
SwissProt: P01194Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.