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货号： bs-9283R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9283R-AF488
- 英文名称
- Anti-RNF187/AF488
- 中文名称
- AF488标记的环指蛋白187抗体
- 别 名
- E3 ubiquitin-protein ligase RNF187; Protein RNF187; RACO-1; RING domain AP1 coactivator 1; RING finger protein 187; RN187_HUMAN; RNF187.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 26kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RNF187
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Subunit:
Interacts with JUN, independently of JUN phosphorylation.
Subcellular Location:
Cytoplasm. Nucleus. Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.
Post-translational modifications:
Ubiquitinated; undergoes Lys-48-linked autoubiquitination in the absence of growth factors and MAP3K1-induced Lys-63-linked polyubiquitination. Lys-48-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced Lys-63-linked polyubiquitination results in the stabilization of the protein. Lys-48- and Lys-63-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded.
Similarity:
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 149603 Human
Entrez Gene: 108660 Mouse
Entrez Gene: 360533 Rat
SwissProt: Q5TA31 Human
SwissProt: Q8BFX1 Mouse
SwissProt: D3Z8N2 Rat
Unigene: 356377 Human
Unigene: 679030 Human
Unigene: 249986 Mouse
Unigene: 100245 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.