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货号： bs-9419R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9419R-AF488
- 英文名称
- Anti-TSPAN10/AF488
- 中文名称
- AF488标记的四分子交联体10抗体（四旋蛋白）
- 别 名
- OCSP; oculospanin; tetraspanin 10; Tspan 10; TSN10_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TSPAN10/Oculospanin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. Oculospanin, also known as tetraspanin 10 (TSPAN10) or OCSP, is a 355 amino acid multi-pass membrane protein belonging to the tetraspanin (TM4SF) family. Oculospanin is expressed in certain regions of the eye such as retinal pigment epithelium, ciliary body and iris, but is not found in the lens. The gene encoding Oculospanin maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is liked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes.
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Tissue Specificity:
Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).
Similarity:
Belongs to the tetraspanin (TM4SF) family.
Database links:Entrez Gene: 83882 Human
SwissProt: Q9H1Z9 Human
Unigene: 208219 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.