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货号： bs-9447R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9447R-AF488
- 英文名称
- Anti-BMP10/AF488
- 中文名称
- AF488标记的骨形态发生蛋白10抗体
- 别 名
- BMP-10; Bmp10; BMP10_HUMAN; Bone morphogenetic protein 10; Bone morphogenetic protein 10 preproprotein; MGC126783.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 信号转导 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 12kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BMP10
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Bone morphogenic proteins (BMPs) are members of the TGF beta superfamily and are involved in the induction of cartilage and bone formation. BMP-10 (Bone morphogenetic protein 10) is a 424 amino acid secreted protein that exists as a disulfide-linked homodimer. Expressed specifically in heart tissue, BMP-10 functions to prevent the premature activation of p57 (a negative cell cycle regulator), thereby maintaining the proliferative activity of embryonic cardiomyocytes and playing a critical role in the formation of trabeculae within the developing heart. Additionally, BMP-10 inhibits the growth and migration of endothelial cells and functions as a ligand for ALK-1, a protein that is tightly linked to angiogenesis. This suggests that, in addition to its role in cardiomyocyte formation, BMP-10 participates in the formation of blood vessels in developing cardiac muscle.
Function:
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted.
Similarity:
Belongs to the TGF-beta family.
Database links:Entrez Gene: 27302 Human
Entrez Gene: 12154 Mouse
Entrez Gene: 500245 Rat
Omim: 608748 Human
SwissProt: O95393 Human
SwissProt: Q9R229 Mouse
SwissProt: Q4AEG6 Rat
Unigene: 158317 Human
Unigene: 483321 Mouse
Unigene: 118010 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.