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货号： bs-11127R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11127R-AF488
- 英文名称
- Anti-CD11b/AF488
- 中文名称
- AF488标记的整合素αM抗体
- 别 名
- Antigen CD11b (p170); CD11 antigen like family member B; CD11 antigen like family member C; CD11B; CD11C; Cell surface glycoprotein MAC 1 subunit alpha; CR 3 alpha chain; CR3A; Integrin alpha M; Integrin alpha X; Integrin, alpha M (complement component 3 receptor 3 subunit); Integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; Leukocyte adhesion receptor p150,95; Leukocyte surface antigen p150,95, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Myeloid membrane antigen, alpha subunit; Neutrophil adherence receptor alpha M subunit; p150 95 integrin alpha chain; SLEB6; ITAM_HUMAN; c equivalent; Integrin αM.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 细胞粘附分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 125kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CD11b
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.
Subcellular Location:
Plasma membrane
Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.
DISEASE:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
Database links:Entrez Gene: 3684Human
Entrez Gene: 16409Mouse
Omim: 120980Human
SwissProt: P11215Human
SwissProt: P05555Mouse
Unigene: 172631Human
Unigene: 262106Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.