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货号： bs-4702R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4702R-AF488
- 英文名称
- Anti-Phospholipase C beta 3/AF488
- 中文名称
- AF488标记的磷酯酶Cβ3
- 别 名
- PLCB3; PLC beta3;1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3;1-phosphatidylinositol-4;5-bisphosphate phosphodiesterase beta-3;Phosphoinositide phospholipase C;Phosphoinositide phospholipase C-beta-3;Phospholipase C beta 3;Phospholipase C beta 3 (phosphatidylinositol specific);Phospholipase C-beta-3;PLC beta 3;PLC-beta-3;Plcb3;PLCB3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 136kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PLC beta3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Function:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Subunit:
Interacts with SHANK2. Interacts with LPAR2.
Subcellular Location:
Membrane; Peripheral membrane protein.
Similarity:
Contains 1 C2 domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC Y-box domain.
Database links:Entrez Gene: 5331Human
Entrez Gene: 18797Mouse
Entrez Gene: 29322Rat
Omim: 600230Human
SwissProt: Q01970Human
SwissProt: P51432Mouse
SwissProt: Q99JE6Rat
Unigene: 523761Human
Unigene: 591953Human
Unigene: 273204Mouse
Unigene: 16983Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.