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货号： bs-11346R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11346R-AF488
- 英文名称
- Anti-EGFLAM/AF488
- 中文名称
- AF488标记的皮卡丘素抗体
- 别 名
- fibronectin type-III and laminin G-like domain-containing protein; Agrin-like protein; AGRINL; AGRNL; EGF-like; EGF-like, fibronectin type III and laminin G domains; EGF-like, fibronectin type-III and laminin G-like domain-containing protein; EGFLA_HUMAN; EGFLAM; FLJ39155; Pikachurin.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 细胞类型标志物 细胞骨架 细胞外基质
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 109kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Pikachurin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
EGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also promote matrix assembly and cell adhesion. Existing as five alternatively spliced isoforms, the gene encoding EGFLAM maps to human chromosome 5p13.2. Chromosome 5 makes up approximately 6% of the human genome and contains 181 million base pairs, which encode 1,000 genes. Cockayne syndrome, Treacher Collins syndrome, acute myelogenous leukemias and myelodysplastic syndrome are associated with genes present on chromosome 5.
Function:
Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness.
Subunit:
Interacts with DAG1 alpha-dystroglycan
Subcellular Location:
Secreted; extracellular space; extracellular matrix. Cell junction > synapse. Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals.
Post-translational modifications:
O-glycosylated; contains chondroitin sulfate and heparan sulfate.
Similarity:
Contains 3 EGF-like domains.
Contains 2 fibronectin type-III domains.
Contains 3 laminin G-like domains.
Database links:Entrez Gene: 133584Human
Entrez Gene: 268780Mouse
Entrez Gene: 365691Rat
Entrez Gene: 534427Cow
SwissProt: A3KN33Cow
SwissProt: Q63HQ2Human
SwissProt: Q4VBE4Mouse
SwissProt: B4F785Rat
Unigene: 20103Human
Unigene: 203208Mouse
Unigene: 27713Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.