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货号： bs-11137R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11137R-AF488
- 英文名称
- Anti-IL-28R/AF488
- 中文名称
- AF488标记的白细胞介素28受体抗体
- 别 名
- Alternative namesIFNLR; Class II cytokine receptor CRF2/12; CRF2/12; Cytokine receptor family 2 member 12; IFN lambda R1; IFNLR1; il-28r1; IL28R alpha; Interferon lambda receptor 1; Interferon lambda receptor; Interleukin 28 receptor alpha chain; LICR2; Likely interleukin or cytokine receptor 2.I28RA_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 55kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-28R
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway.
Function:
IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.
Subunit:
Heterodimer with IL10RB.
Subcellular Location:
Membrane; Single-pass type I membrane protein
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the type II cytokine receptor family.
Contains 1 fibronectin type-III domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.