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货号： bs-11499R-AF488 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11499R-AF488
- 英文名称
- Anti-ARMETL1/AF488
- 中文名称
- AF488标记的脑多巴胺神经营养因子抗体
- 别 名
- CDNF; Arginine rich mutated in early stage tumors like 1; ARMET L1; ARMET like protein 1; ARMET-like protein 1; ARMETL 1; Cdnf; CDNF_HUMAN; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 18kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ARMETL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CDNF is an ARMET family member that is known to be a trophic factor for dopamine neurons. CDNF has been shown to prevent the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. CDNF application will restore the dopaminergic function that is reduced by lesions formed from administering 6-OHDA. CDNF further prevents the degeneration of dopaminergic neurons in substantia nigra. CDNF is expressed at high levels in the heart, skeletal muscle, testis and brain. In brain, CDNF has selective expression with the highest being detected in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus.
Function:
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
Subcellular Location:
Secreted.
Tissue Specificity:
Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
Similarity:
Belongs to the ARMET family.
Database links:Entrez Gene: 441549Human
Omim: 611233Human
SwissProt: Q49AH0Human
Unigene: 559067Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.