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货号： bs-23050R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23050R-AF350
- 英文名称
- Anti-Kisspeptin/AF350
- 中文名称
- AF350标记的肿瘤转移抑制基因抗体
- 别 名
- AXOR 12; AXOR12; G protein coupled receptor 54; GPCR 54; GPCR54; GPR 54; GPR54; HOT7T175; Hypogonadotropin 1; Hypogonadotropin1; KISS 1 receptor; KISS 1R; KISS1 receptor; KISS1R; Kisspeptins receptor; metastin receptor; KISS 1; KiSS 1 metastasis suppressor; KISS-1; KISS1_HUMAN; Kisspeptin 1; Kisspeptin 10; Kisspeptin 13; Kisspeptin 14; Kisspeptin; Kisspeptin-1; Kisspeptin-10; Kisspeptin-54; Kisspeptin1; Malignant melanoma metastasis suppressor; Metastasis suppressor KiSS 1; Metastasis suppressor KiSS1; Metastin; MGC39258.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 16kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Kisspeptin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
Function:
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Subcellular Location:
Secreted.
Tissue Specificity:
Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
Post-translational modifications:
Processed by MMP2 and MMP9.
Similarity:
Belongs to the KISS1 family.
Database links:Entrez Gene: 3814 Human
Entrez Gene: 289023 Rat
Omim: 603286 Human
SwissProt: Q15726 Human
SwissProt: Q7TSB7 Rat
Unigene: 95008 Human
Unigene: 66008 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Kiss-1主要用于肿瘤及肿瘤转移方面的研究。近年来Kiss-1与MMP-9、MMP-2 是肿瘤转移、浸润研究的热门课题。