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货号： bs-20405R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20405R-AF350
- 英文名称
- Anti-Hrasls3/AF350
- 中文名称
- AF350标记的HRAS样抑制因子3抗体
- 别 名
- H rev 107 protein homolog; HRAS like suppressor 3; HREV107 3; HREV107; Renal carcinoma antigen NY REN 65; Adipose specific phospholipase A2; Group XVI phospholipase A2; HREV107; HRSL3_MOUSE; AdPLA; HRSL3; HRASLS3; HREV107-1; HREV107-3; H-REV107-1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 18kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Hrasls3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HRASLS3 specifically catalyzes the release of fatty acids from phospholipids in adipose tissue and also has a weak lysophospholipase activity. It is a tumor suppressor that may be involved in interferon-dependent cell death.
Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N-and O-acylation activity is hardly detectable. Also has weak lysophospholipase activity.
Subunit:
Interacts with PPP2R1A; this interaction might decrease PP2A activity.
Subcellular Location:
Membrane; Single-pass membrane protein (Potential). Cytoplasm. Cytoplasm, perinuclear region.
Tissue Specificity:
Ubiquitously expressed in normal tissues but down-regulated in primary carcinomas or in many cell lines derived from tumors. Highly expressed in white adipose tissue and in adipocytes. Expressed at lower levels in brown adipose tissue.
Similarity:
Belongs to the H-rev107 family.
Database links:Entrez Gene: 11145 Human
Entrez Gene: 225845 Mouse
Omim: 613867 Human
SwissProt: P53816 Human
SwissProt: Q8R3U1 Mouse
Unigene: 502775 Human
Unigene: 274810 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.