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货号： bs-20549R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20549R-AF350
- 英文名称
- Anti-ANKRD54/AF350
- 中文名称
- AF350标记的锚蛋白重复域54抗体
- 别 名
- Ankrd54; ankyrin repeat domain 54; ankyrin repeat domain 54; Ankyrin repeat domain-containing protein 54; ANR54_HUMAN; LIAR.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ANKRD54
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ANKRD54 is a 300 amino acid protein that contains four ankyrin repeats and is expressed as two alternatively spliced isoforms. The gene encoding human ANKRD54 maps to chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Subunit:
Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN (By similarity). Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.
Subcellular Location:
Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation.
Similarity:
Contains 4 ANK repeats.
Database links:Entrez Gene: 129138 Human
Entrez Gene: 223690 Mouse
Entrez Gene: 362957 Rat
Omim: 613383 Human
SwissProt: Q6NXT1 Human
SwissProt: Q91WK7 Mouse
SwissProt: Q566C8 Rat
Unigene: 135259 Human
Unigene: 24262 Mous
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.