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货号： bs-12965R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12965R-AF350
- 英文名称
- Anti-TAF4B/AF350
- 中文名称
- AF350标记的转录起始因子TFIID亚基4B抗体
- 别 名
- TAF(II)105; TAF2C2; TAF4b RNA polymerase II, TATA box binding protein (TBP) associated factor, 105kDa; TAFII 105; TAFII105; TAFII105ALPHA; TATA box binding protein (TBP) associated factor 4B; TATA box binding protein (TBP) associated factor, RNA polymerase II, C2, 105kD; Transcription initiation factor TFIID 105 kD subunit; Transcription initiation factor TFIID 105 kDa subunit; Transcription initiation factor TFIID subunit 4B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 b-淋巴细胞 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 91kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TAF4B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Function:
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Subunit:
TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.
Subcellular Location:
Nucleus. Cytoplasm. Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Tissue Specificity:
Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.
Post-translational modifications:
Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.Disease description:A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
Similarity:
Belongs to the TAF4 family.
Contains 1 histone-fold domain.
Contains 1 TAFH (NHR1) domain.
Database links:Entrez Gene: 6875Human
Omim: 601689Human
SwissProt: Q92750Human
Unigene: 369519Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.