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货号： bs-12668R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12668R-AF350
- 英文名称
- Anti-TMEPAI/AF350
- 中文名称
- AF350标记的跨膜前列腺雄激素诱导蛋白1抗体
- 别 名
- PMEPA_HUMAN; PMEPA1; Prostate transmembrane protein, androgen induced 1; Solid tumor associated 1 protein; Solid tumor-associated 1 protein; STAG1; Transmembrane prostate androgen induced protein; Transmembrane prostate androgen-induced protein; Transmembrane, prostate androgen induced RNA.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 生长因子和激素 跨膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TMEPAI
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Function:
Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Highest expression in prostate. Also expressed in ovary.
Similarity:
Belongs to the PMEPA1 family.
Database links:Entrez Gene: 56937Human
Omim: 606564Human
SwissProt: Q969W9Human
Unigene: 517155Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.