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货号： bs-12658R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12658R-AF350
- 英文名称
- Anti-SNRP70/AF350
- 中文名称
- AF350标记的SNRP70蛋白抗体
- 别 名
- RNPU1Z; Rnulp70; RPU1; Small nuclear ribonucleoprotein 70 (U1); Small nuclear ribonucleoprotein 70kD polypeptide (RNP antigen); Small nuclear ribonucleoprotein 70kDa (U1); Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen); snRNP70; Snrp 70; SNRP70; U1 70K; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein polypeptide A; U1 snRNP 70 kDa; U170K; U1AP; U1AP1; U1RNP.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SNRP70
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SNRP70 is an RNA-binding protein that is a specific component of the U1 small nuclear ribonucleoprotein complex and constitutes the major anti-(U1) RNP autoimmune antigen. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Subunit:
U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2.
Subcellular Location:
Nuclear.
Post-translational modifications:
The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 6625Human
Entrez Gene: 20637Mouse
Entrez Gene: 361574Rat
Omim: 180740Human
SwissProt: P08621Human
SwissProt: Q62376Mouse
Unigene: 467097Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.