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货号： bs-12586R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12586R-AF350
- 英文名称
- Anti-PDE6D/AF350
- 中文名称
- AF350标记的磷酸二酯酶6δ抗体
- 别 名
- PDE6 delta;5-cyclic phosphodiesterase subunit delta; GMP PDE delta; GMP-PDE delta; p17 protein; PDE 6; PDE 6D; PDE D; PDE6; PDE6D; PDE6D_HUMAN; PDED; Phosphodiesterase 6D cGMP specific; Phosphodiesterase 6D cGMP specific rod delta; Protein p17; Retinal rod photoreceptor cGMP phosphodiesterase delta; Retinal rod rhodopsin sensitive cGMP 3 5 cyclic phosphodiesterase subunit delta; Retinal rod rhodopsin-sensitive cGMP 3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Zebrafish,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PDE6D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]
Function:
Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation.
Tissue Specificity:
Retina.
Similarity:
Belongs to the PDE6D/unc-119 family.
Database links:Entrez Gene: 281976Cow
Entrez Gene: 403781Dog
Entrez Gene: 5147Human
Entrez Gene: 18582Mouse
Entrez Gene: 363272Rat
Omim: 602676Human
SwissProt: Q95142Cow
SwissProt: Q9XT54Dog
SwissProt: O43924Human
SwissProt: O55057Mouse
Unigene: 516808Human
Unigene: 12925Mouse
Unigene: 44816Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.