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货号： bs-21039R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-21039R-AF350
- 英文名称
- Anti-ROGDI/AF350
- 中文名称
- AF350标记的亮氨酸拉链结构域蛋白ROGDI抗体
- 别 名
- FLJ22386; KTZS; Leucine zipper domain protein; Protein rogdi homolog; rogdi; rogdi homolog (Drosophila); rogdi, Drosophila, homolog of; ROGDI_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 神经生物学 细胞周期蛋白 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ROGDI
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Function:
May act as a positive regulator of cell proliferation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed with highest levels in spinal cord, brain, heart and bone marrow. Also expressed in fetal brain and liver.
DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:An autosomal recessive disorder characterized by severe global developmental delay, early-onset intractable seizures, spasticity, and amelogenesis imperfecta affecting both primary and secondary teeth and causing yellow or brown discoloration of the teeth. Although the phenotype is consistent, there is variability. Intellectual disability is related to the severity of seizures, and the disorder can thus be considered an epileptic encephalopathy. Some infants show normal development until seizure onset, whereas others are delayed from birth. The most severely affected individuals have profound mental retardation, never acquire speech, and become bedridden early in life.
Similarity:
Belongs to the rogdi family.
Database links:Entrez Gene: 79641Human
Entrez Gene: 66049Mouse
Entrez Gene: 287061Rat
Omim: 614574Human
SwissProt: Q9GZN7Human
SwissProt: Q3TDK6Mouse
SwissProt: Q4V7D2Rat
Unigene: 459795Human
Unigene: 27792Mouse
Unigene: 995Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.