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货号： bs-19857R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19857R-AF350
- 英文名称
- Anti-RGS17/AF350
- 中文名称
- AF350标记的G蛋白信号转导调节因子17抗体
- 别 名
- Regulator of G protein signalling 17; RGS17 / RGSZ2; Regulator of G protein signalling Z2; Regulator of G-protein signaling 17; RGS17; RGS17_HUMAN; RGSZ2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RGS17
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
Subcellular Location:
Membrane. Nucleus. Cytoplasm. Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
Tissue Specificity:
Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.
Post-translational modifications:
Fatty acylated. Heavily palmitoylated in the cysteine string motif.N- and O-glycosylated in synapsomal membranes.Serine phosphorylated in synapsomal membranes.
Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
Similarity:
Contains 1 RGS domain.
Database links:Entrez Gene: 504255Cow
Entrez Gene: 608867Dog
Entrez Gene: 100712640 Guinea pig
Entrez Gene: 100060098Horse
Entrez Gene: 26575Human
Entrez Gene: 56533Mouse
Entrez Gene: 100514020Pig
Entrez Gene: 100349762Rabbit
Entrez Gene: 308118Rat
Omim: 607191Human
SwissProt: Q9UGC6Human
SwissProt: Q9QZB0Mouse
Unigene: 166313Human
Unigene: 44606Mouse
Unigene: 166916Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.