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货号： bs-12130R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12130R-AF350
- 英文名称
- Anti-ACCN5/AF350
- 中文名称
- AF350标记的小肠钠通道蛋白5抗体
- 别 名
- amiloride sensitive cation channel 5, intestinal; Amiloride sensitive sodium channel;intestine Na+ channel; amiloride-sensitive cation channel 5; HINAC; INAC; ASIC5_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 通道蛋白 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ACCN5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ACCN5 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. DEG/ENaC superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and C-termini, two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Localizing to the cell membrane, ACCN5 is a multi-pass membrane protein that is expressed in small intestine, jejunum and duodenum. ACCN5 is also expressed at low levels in rectum and testis. Existing as a homo- or heterotetramer, ACCN5 functions as a Na+-selective cation channel that, characteristic of its family, can be inhibited by amiloride.
Function:
ACCN5 belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known.
Subunit:
Homotrimer or heterotrimer with other ASIC proteins.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.
Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.
Database links:Entrez Gene: 51802 Human
SwissProt: Q9NY37 Human
Unigene: 381349 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.