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货号： bs-12081R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12081R-AF350
- 英文名称
- Anti-GABARE/AF350
- 中文名称
- AF350标记的G氨基丁酸受体ε/GABAA Rε抗体
- 别 名
- GABA Receptor Epsilon; GABA(A) receptor epsilon; GABA(A) receptor subunit epsilon; Gabre; Gamma aminobutyric acid (GABA) A receptor epsilon; Gamma aminobutyric acid receptor subunit epsilon; Gamma-aminobutyric acid receptor subunit epsilon; GBRE_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 56kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GABARE/GABA Receptor Epsilon
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]
Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit:
Generally pentameric. Associates with alpha and beta subunits.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in many tissues. Highest levels of expression in adult heart and placenta.
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
GABRE sub-subfamily.
Database links:Entrez Gene: 2564Human
Entrez Gene: 65191Rat
Omim: 300093Human
SwissProt: P78334Human
SwissProt: Q9ES14Rat
Unigene: 22785Human
Unigene: 54455Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.