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货号： bs-11936R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11936R-AF350
- 英文名称
- Anti-Plexin A4/AF350
- 中文名称
- AF350标记的神经丛蛋白A4抗体
- 别 名
- FAYV2820; KIAA1550; PLEXA4; Plexin-A4; PlexinA4; PLXA4_HUMAN; PLXNA4; PLXNA4A; PLXNA4B; PRO34003; UNQ2820/PRO34003.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 发育生物学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 210kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Plexin A4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Forms a receptor complex with neuropilin-1 and can propagate semaphorin-3A elicited inhibitory signals into cells and neurons.
Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm
Subunit:
Interacts with NRP1 and NRP2
Subcellular Location:
Cell membrane; Single-pass type I membrane protein
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 3 PSI domains.
Contains 1 Sema domain.
Database links:Entrez Gene: 91584 Human
Entrez Gene: 243743 Mouse
Entrez Gene: 312213 Rat
Omim: 604280 Human
SwissProt: Q9HCM2 Human
SwissProt: Q80UG2 Mouse
Unigene: 511454 Human
Unigene: 444029 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.