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货号： bs-0276R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0276R-AF350
- 英文名称
- Anti-SSB/AF350
- 中文名称
- AF350标记的干燥症SSB/La抗体
- 别 名
- SSB; Lupus La protein homolog; La ribonucleoprotein; La autoantigen homolog; Sjogren syndrome type B antigen; LA_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 47kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SSB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Lupus La protein (Sjogren syndrome type B antigen) (SS-B) (La ribonucleoprotein) (La autoantigen) plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3 termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs. The phosphorylation sites are at the C-terminal part of the protein. Sera from patients with systemic lupus erythematosus(SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.
Function:
Binds to the 3 poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subunit:
Interacts with DDX15. May interact with RUFY1.
Subcellular Location:
Nucleus (Probable).
Post-translational modifications:
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
The N-terminus is blocked.
Similarity:
Contains 1 HTH La-type RNA-binding domain.
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 20823Mouse
Entrez Gene: 6741 Human
Entrez Gene: 20823 Mouse
Entrez Gene: 81783 Rat
GenBank: NP_003133.1 Human
Omim: 109090 Human
SwissProt: P05455 Human
SwissProt: P32067 Mouse
SwissProt: P38656 Rat
Unigene: 632535 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同SSA,广泛应用于各种自身免疫性疾病检测.