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货号： bs-4224R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4224R-AF350
- 英文名称
- Anti-UGT1A9/AF350
- 中文名称
- AF350标记的尿苷二磷酸葡萄糖醛酸转移酶1A9
- 别 名
- GNT1; HLUGP4; LUGP4; UDP glucuronosyltransferase 1A9; UDPGT; UGT1I; UD19_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human UGT1A9
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
UGT1A9 is a UDP glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N termini and identical C termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. UGT1A9 is active on phenols.
Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
Subcellular Location:
Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).
Tissue Specificity:
Liver.
Similarity:
Belongs to the UDP-glycosyltransferase family.
Database links:
UniProtKB/Swiss-Prot: O60656.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.