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货号： bs-2918R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2918R-AF350
- 英文名称
- Anti-RAP1GAP/AF350
- 中文名称
- AF350标记的RAP1GAP酶激活蛋白抗体
- 别 名
- Rap1 GTPase activating protein 1; RAP1 GTPase activating protein; RAP1GA1; Rap1ga1 protein; RAP1GAP1; RAP1GAPII; RAPGAP; KIAA0474; RPGP1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 73kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RAP1GAP.
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
RAP1GAP, an 85/95kDa protein, is a member of a family of GAPs specific for Rap1. Though to be an important tumor suppressor, Rap1GAP has no sequence homology with other GAPs such as RasGAP, RanGAP and RhoGAP. Purified as a cytosolic and membrane-bound protein, both isoforms consist of two monomers each contain a dimerization and a catalytic domain. Mutations in the GAP domain of the tumor suppressor tuberin, can cause benign tumor phenotype tuberous sclerosis. There are 2 isoforms produced by alternative splicing.
Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Subunit:
Homodimer and heterodimer with RAP1B.
Subcellular Location:
Golgi apparatus membrane; Peripheral membrane protein.
Tissue Specificity:
Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
Similarity:
Contains 1 GoLoco domain.
Contains 1 Rap-GAP domain.
Database links:Entrez Gene: 5909 Human
Entrez Gene: 110351 Mouse
Entrez Gene: 313644 Rat
Omim: 600278 Human
SwissProt: P47736 Human
SwissProt: A2ALS5 Mouse
Unigene: 148178 Human
Unigene: 180763 Mouse
Unigene: 18036 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RaplGAP在细胞的粘附连接及形成过程中所发挥着一定作用。RaplGAP是小分子G蛋白Rapl的GTP酶激活蛋白(GTPase activating protein)，它可以加速rap1由活化形式(与GTP结合)转变为去活化形式(与GDP结合)。由于粘附连接的破坏或延迟了粘附连接形成的过程，对肿瘤转移有着密切的联系。