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货号： bs-5803R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5803R-AF350
- 英文名称
- Anti-API2/BIRC3/AF350
- 中文名称
- AF350标记的凋亡抑制因子2抗体
- 别 名
- cIAP2; CIAP 2; CIAP-2; Inhibitor of apoptosis protein 1; AIP 1; AIP1; API 2; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3_HUMAN; C IAP2; C-IAP2; CIAP 2; CIAP2; HAIP 1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human cIAP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Function:
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Subunit:
Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
DISEASE:
Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
Similarity:
Belongs to the IAP family.
Contains 3 BIR repeats.
Contains 1 CARD domain.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 330Human
Entrez Gene: 11796Mouse
Entrez Gene: 78971Rat
Omim: 601721Human
SwissProt: Q13489Human
SwissProt: O08863Mouse
Unigene: 127799Human
Unigene: 2026Mouse
Unigene: 64578Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.