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货号： bs-5938R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5938R-AF350
- 英文名称
- Anti-DAT1/LIM domain only 3/AF350
- 中文名称
- AF350标记的神经细胞特异性转录因子DAT1抗体
- 别 名
- DAT 1; DAT1; LIM domain only 3 (rhombotin like 2); LIM domain only protein 3; LMO 3; LMO3; Neuronal specific transcription factor DAT1; RBTN 3; RBTN3; RBTNL 2; RBTNL2; RHOM 3; RHOM3; Rhombotin 3; Rhombotin like 2; Rhombotin3; LMO3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 16kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DAT1/LIM domain only 3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LIM domain only 3 (LMO3) belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. It is transcribed mainly in the brain. It interacts with the neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.
Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Subcellular Location:
Membrane.
DISEASE:
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.
Similarity:
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Database links:Entrez Gene: 55885Human
Entrez Gene: 109593Mouse
Omim: 180386Human
SwissProt: Q8TAP4Human
SwissProt: Q8BZL8Mouse
SwissProt: Q99MB5Rat
Unigene: 504908Human
Unigene: 485195Mouse
Unigene: 25503Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.