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货号： bs-6006R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6006R-AF350
- 英文名称
- Anti-FBXO31/AF350
- 中文名称
- AF350标记的F-box蛋白家族FBXO31抗体
- 别 名
- F box only protein 31; FBX14; FBX31; FBXO14; pp2386; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor; FBX31_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 61kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FBXO31 (170-225aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
FBXO31 belongs to the F-box protein family. Such proteins are characterized by an F-box motif of approximately 40 residues. F-box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains. There are two different isoforms.
Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Tissue Specificity:
Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
Post-translational modifications:
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.
Similarity:
Belongs to the FBXO31 family.
Contains 1 F-box domain.
Database links:Entrez Gene: 79791 Human
Entrez Gene: 76454 Mouse
Omim: 609102 Human
SwissProt: Q5XUX0 Human
SwissProt: Q3TQF0 Mouse
Unigene: 567582 Human
Unigene: 467749 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.