产品中心
当前位置：首页>产品中心Anti-SH2D3A/AF350
货号： bs-6158R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6158R-AF350
- 英文名称
- Anti-SH2D3A/AF350
- 中文名称
- AF350标记的SH2结构域蛋白3A抗体
- 别 名
- Novel SH2 containing protein 1; NSP1; SH2 domain containing 3A; SH2 domain containing protein 3A; SH23A_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 转录调节因子 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Pig, Cow, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 63kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NSP1/SH2D3A
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SH2D3A is a 576 amino acid protein that is thought to play a role in JNK activation. SH2D3A interacts with p130 Cas and is found at low levels in fetal kidney, fetal lung, placenta, adult pancreas, kidney and lung. Subject to post-translational phosphorylation on multiple tyrosine residues, SH2D3A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. The gene encoding SH2D3A maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs).
Function:
May play a role in JNK activation.
Subunit:
Interacts with BCAR1.
Tissue Specificity:
Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
Post-translational modifications:
Phosphorylated on tyrosine.
Similarity:
Contains 1 SH2 domain.
Database links:
Entrez Gene: 10045Human
GenBank: BC006281Human
Omim: 604721Human
SwissProt: Q9BRG2Human
Unigene: 439645Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.