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货号： bs-6180R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6180R-AF350
- 英文名称
- Anti-Rab3A+Rab3B+Rab3C+Rab3D/AF350
- 中文名称
- AF350标记的ras癌基因家族Rab3A--Rab3D抗体
- 别 名
- RAB3A; RAB3A member RAS oncogene family; RAB3B; RAB3B member RAS oncogene family; RAB3C; RAB3C member RAS oncogene family; RAB3D member RAS oncogene family; RAD3D; Ras related protein Rab 3A; Ras related protein Rab 3B; Ras related protein Rab 3C; Ras related protein Rab 3D; D2 2; Glioblastoma overexpressed; GOV; RAB16.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导 转录调节因子 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24-27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Rab3A+Rab3B+Rab3C+Rab3D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has four known isoforms: 3A, 3B, 3C and 3D. These proteins are expressed in the highest concentration in the brain and endocrine tissues and are involved in regulated exocytosis of hormones and neurotransmitters. Specifically Rab3s are thought to play a role in presynaptic vesicle trafficking and priming.
Function:
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Subunit:
Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.
Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Tissue Specificity:
Specifically expressed in brain.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
Database links:Entrez Gene: 115827 Human
Entrez Gene: 5864 Human
Entrez Gene: 5865 Human
Entrez Gene: 9545 Human
Entrez Gene: 19339 Mouse
Entrez Gene: 19340 Mouse
Entrez Gene: 67295 Mouse
Entrez Gene: 69908 Mouse
Entrez Gene: 140665 Rat
Entrez Gene: 171058 Rat
Entrez Gene: 25531 Rat
Entrez Gene: 81755 Rat
Entrez Gene: 399230 Xenopus laevis
Entrez Gene: 495404 Xenopus laevis
Omim: 179490 Human
Omim: 179510 Human
Omim: 604350 Human
SwissProt: O95716 Human
SwissProt: P20336 Human
SwissProt: P20337 Human
SwissProt: Q5VUL2 Human
SwissProt: Q96E17 Human
SwissProt: P35276 Mouse
SwissProt: P62823 Mouse
SwissProt: P63011 Mouse
SwissProt: Q0PD62 Mouse
SwissProt: Q0PD63 Mouse
SwissProt: Q9CZT8 Mouse
SwissProt: Q9JME6 Mouse
SwissProt: P62824 Rat
SwissProt: P63012 Rat
SwissProt: Q63941 Rat
SwissProt: Q63942 Rat
SwissProt: Q6P9W6 Rat
SwissProt: Q3KQA5 Xenopus laevis
Unigene: 123072 Human
Unigene: 27744 Human
Unigene: 482173 Human
Unigene: 8036 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.