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货号： bs-6193R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6193R-AF350
- 英文名称
- Anti-SMYD2/AF350
- 中文名称
- AF350标记的组蛋白甲基转移酶SMYD2抗体
- 别 名
- HSKM B; HSKM-B; HSKMB; Histone methyltransferase SMYD2; HSKM-B; Lysine N-methyltransferase 3C; MGC119305; N lysine methyltransferase SMYD2; N-lysine methyltransferase SMYD2; SET and MYND domain containing 2; SET and MYND domain containing protein 2; SET and MYND domain-containing protein 2; Smyd2; SMYD2_HUMAN; Zinc finger MYND domain containing 14; ZMYND14.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SMYD2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 Lys-4 (H3K4me) and dimethylates histone H3 Lys-36 (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates Lys-370 of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates Lys-860 of RB1/RB.
Function:
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 Lys-4 (H3K4me) and dimethylates histone H3 Lys-36 (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates Lys-370 of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates Lys-860 of RB1/RB.
Subunit:
Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1.
Subcellular Location:
Cytoplasm, cytosol (By similarity). Nucleus (By similarity).
Similarity:
Contains 1 MYND-type zinc finger.
Contains 1 SET domain.
Database links:Entrez Gene: 56950 Human
Entrez Gene: 226830 Mouse
Entrez Gene: 100294706 Pig
Entrez Gene: 289372 Rat
Omim: 610663 Human
SwissProt: Q0P585 Cow
SwissProt: Q9NRG4 Human
SwissProt: Q8R5A0 Mouse
SwissProt: C3RZA1 Pig
SwissProt: Q7M6Z3 Rat
Unigene: 66170 Human
Unigene: 156895 Mouse
Unigene: 7052 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.