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货号： bs-6637R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6637R-AF350
- 英文名称
- Anti-TP53I8/AF350
- 中文名称
- AF350标记的肿瘤蛋白p53诱导蛋白8
- 别 名
- Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 肿瘤细胞生物标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TP53I8/EI24 (256-300aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function:
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.
Subunit:
Interacts with BCL2.
Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
DISEASE:
Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
Similarity:
Belongs to the EI24 family.
Database links:Entrez Gene: 9538 Human
Entrez Gene: 13663 Mouse
Entrez Gene: 300514 Rat
Omim: 605170 Human
SwissProt: O14681 Human
SwissProt: Q61070 Mouse
SwissProt: Q4KM77 Rat
Unigene: 643514 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.