Anti-CLUAP1/AF350【科瑞奥博】

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货号： bs-6805R-AF350 基本售价： 2980.0 元规格： 100ul

产品应用: IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

保存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍: background:
CLUAP1 (Clusterin associated protein 1) is a 413 amino acid nuclear protein that exists as two alternatively spliced isoforms that interact with Clusterin. CLUAP1 is suggested to play a role in apoptosis and cell proliferation, and is expressed in testis, thrachea and thyroid, with low levels found in adrenal gland and spinal cord. The gene encoding CLUAP1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohns disease, which is a gastrointestinal inflammatory condition.

Function:
May play a role in cell proliferation or apoptosis.

Subunit:
Interacts with CLU/clusterin.

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland.

Database links:
UniProtKB/Swiss-Prot: Q96AJ1.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.