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货号： bs-7550R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7550R-AF350
- 英文名称
- Anti-AUP1/AF350
- 中文名称
- AF350标记的原始广泛存在蛋白1抗体
- 别 名
- AA589454; AUP 1; AUP1; AUP1_HUMAN; Ancient ubiquitous protein 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human AUP1/Ancient ubiquitous protein 1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Ancient ubiquitous protein 1 (AUP1) contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. It has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits.
Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
Subunit:
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.
Tissue Specificity:
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Similarity:
Belongs to the AUP1 family.
Contains 1 CUE domain.
Database links:Entrez Gene: 550 Human
Entrez Gene: 11993 Mouse
Entrez Gene: 680423 Rat
Omim: 602434 Human
SwissProt: Q9Y679 Human
SwissProt: P70295 Mouse
SwissProt: A1L134 Rat
Unigene: 411480 Human
Unigene: 386752 Mouse
Unigene: 198163 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.