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货号： bs-7085R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7085R-AF350
- 英文名称
- Anti-CARD4/AF350
- 中文名称
- AF350标记的凋亡加强结构域蛋白4抗体
- 别 名
- CARD 4; CARD4; Caspase recruitment domain 4; Caspase recruitment domain containing protein 4; Caspase recruitment domain family member 4; Caspase recruitment domain protein 4; Caspase recruitment domain-containing protein 4; CLR 7.1; CLR7.1; NLR family CARD domain containing 1; NLRC 1; NLRC1; NOD 1; Nod1; NOD1 protein; NOD1_HUMAN; Nucleotide binding oligomerization domain containing 1; Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1; Nucleotide-binding oligomerization domain-containing protein 1; Protein Nod1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 108kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CARD4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.
Subunit:
Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2.
Subcellular Location:
Cytoplasm. Basolateral cell membrane. Recruited to the basolateral membrane compartment in polarized epithelial cells.
Tissue Specificity:
Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
Similarity:
Contains 1 CARD domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Database links:Entrez Gene: 10392Human
Entrez Gene: 107607Mouse
Entrez Gene: 500133Rat
Omim: 605980Human
SwissProt: Q9Y239Human
SwissProt: Q8BHB0Mouse
Unigene: 405153Human
Unigene: 28498Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.