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货号： bs-7813R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7813R-AF350
- 英文名称
- Anti-NEDD1/AF350
- 中文名称
- AF350标记的神经前体细胞表达蛋白1抗体
- 别 名
- GCP WD; Neural precursor cell expressed, developmentally down regulated gene 1; TUBGCP7; FLJ35902; NEDD1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 干细胞 细胞周期蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 72kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NEDD1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
May play an important role during the embryonic development and differentiation of the central nervous system. Human NEDD1 localises to the centrosome and mitotic spindle. It binds to the components of the gamma-tubulin ring complex and target this complex to the centrosome and spindle.
Function:
Required for mitosis progression. Promotes thenucleation of microtubules from the spindle.
Subunit:
Interacts with FAM29A and gamma-tubulin.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.
Post-translational modifications:
During mitosis, prior phosphorylation on Thr-550 by CDK1promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397,Ser-426 and Ser-637. Phosphorylated NEDD1 can interact withgamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC)to the centrosome, an important step for spindle formation.
Similarity:
Contains 8 WD repeats.
Database links:
UniProtKB/Swiss-Prot: Q8NHV4.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.