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货号： bs-7767R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7767R-AF350
- 英文名称
- Anti-phospho-RACGAP1(Ser387)/AF350
- 中文名称
- AF350标记的磷酸化Rho GTP酶激活蛋白GAP抗体
- 别 名
- RACGAP1 (phospho S387); p-RACGAP1(S387); p-RACGAP1(Ser387; GAP; Gap1; GTPase activating protein; HsCYK 4; HsCYK4; ID GAP; KIAA1478; MgcRacGAP; Rac GTPase activating protein 1; RACGAP 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 信号转导 转录调节因子 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 71kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human RACGAP1 around the phosphorylation site of Ser387.
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.
Subunit:
Heterotetramer of two molecules each of RACGAP1 and KIF23.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle.
Tissue Specificity:
Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase.
Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.