Anti-CCDC22/AF350【科瑞奥博】

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货号： bs-8124R-AF350 基本售价： 2980.0 元规格： 100ul

产品应用: IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

保存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍: background:
This gene encodes a protein containing a coiled-coil domain. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. Localization of the orthologous rat protein suggests that it may play a role in neuronal injury response. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2011].

Subunit:
Interacts with CPNE1 and CPNE4 (By similarity).

Tissue Specificity:
Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.

DISEASE:
Note=May be involved in X-linked syndromic mental retardation (PubMed:21826058). CCDC22 expression has been found to be down-regulated in a family with a phenotype consistent with X-linked syndromic mental retardation, and carrying variant Ala-17. In addition to intellectual disability, affected individuals have cardiac and skeletal abnormalities.

Similarity:
Belongs to the CCDC22 family.

Database links:
UniProtKB/Swiss-Prot: O60826.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.