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货号： bs-8271R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8271R-AF350
- 英文名称
- Anti-GIMAP5/AF350
- 中文名称
- AF350标记的GTP酶IMAP家族成员5抗体
- 别 名
- HIMAP3; IAN4; IAN4L1; IAN5; IMAP3; FLJ11296; GIMAP 5; GTPase IMAP family member 5; GTPase, IMAP family member 5; immunity-associated nucleotide 5; hIAN5; IAN 5; Immune associated nucleotide 4 like 1; Immunity associated nucleotide 4 like 1 protein; Immunity associated protein 3; GIMA5_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导 t-淋巴细胞 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 35kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from huam GIMAP5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.
Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).
Subcellular Location:
Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome.
Tissue Specificity:
Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.
Similarity:
Belongs to the IAN GTP-binding protein family.
Database links:
UniProtKB/Swiss-Prot: Q96F15.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.