Anti-UBE2U/AF350【科瑞奥博】

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货号： bs-8384R-AF350 基本售价： 2980.0 元规格： 100ul

别名: UBE2U; UBE2U_HUMAN; Ubiquitin carrier protein U; Ubiquitin-conjugating enzyme E2 U; Ubiquitin-protein ligase U.

产品应用: IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

保存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍: background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires ATP-dependent activation of the Ub C-terminus and assembly of multi-Ub chains by a Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2U (ubiquitin-conjugating enzyme E2U) is a 321 amino acid E2 ubiquitin conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. Existing as two alternatively spliced isoforms, UBE2U is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).

Similarity:
Belongs to the ubiquitin-conjugating enzyme family.

Database links:
UniProtKB/Swiss-Prot: Q5VVX9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.