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货号： bs-9170R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9170R-AF350
- 英文名称
- Anti-RNF40/AF350
- 中文名称
- AF350标记的环指蛋白40抗体
- 别 名
- BRE1 E3 ubiquitin ligase homolog B; BRE1-B; BRE1B; BRE1B_HUMAN; E3 ubiquitin protein ligase BRE1B; E3 ubiquitin-protein ligase BRE1B; Rb associated protein; RBP 95; RBP95; Ring finger protein 40; RNF 40; Rnf40; STARING; 95 kDa retinoblastoma associated protein; 95 kDa retinoblastoma protein binding protein; 95 kDa retinoblastoma-associated protein; BRE 1B; BRE1 B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 110kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RNF40
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF40 (RING finger protein 40), also known as BRE1B, Staring or RBP95, is a 1,001 amino acid nuclear protein that contains one RING-type zinc finger. Expressed ubiquitously with highest expression in heart, testis and pancreas, RNF40 functions as an E3 ubiquitin-protein ligase that regulates the monoubiquitination and subsequent degradation of select residues on target proteins, such as Histone H2B and Syntaxin 1. In addition, RNF40 forms a ubiquitin ligase complex with UBCH6 (an E2 enzyme) and together, these proteins play a crucial role in regulation of the histone code. Four isoforms of RNF40 exist due to alternative splicing events.
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of Lys-120 of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation (H3K4me and H3K79me, respectively). Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes.
Subunit:
Homodimer. Component of the RNF20/40 complex at least composed of 2 copies of RNF20/BRE1A, 2 copies of RNF40/BRE1B and UBE2E1/UBCH6. Interacts with RB1 and WAC.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
Similarity:
Belongs to the BRE1 family.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 9810 Human
Omim: 607700 Human
SwissProt: O75150 Human
Unigene: 65238 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.