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货号： bs-9458R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9458R-AF350
- 英文名称
- Anti-TNNI3K/AF350
- 中文名称
- AF350标记的丝氨酸/苏氨酸蛋白激酶TNN13K抗体
- 别 名
- Cardiac ankyrin repeat kinase; CARK; MGC142099; MGC33828; Serine/threonine protein kinase TNN13K; Serine/threonine-protein kinase TNNI3K; TNI3K_HUMAN; TNNI3 interacting kinase; TNNI3-interacting kinase; Tnni3k.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 93kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TNNI3K
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TNNI3K, also known as CARK, is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events.
Function:
May play a role in cardiac physiology.
Subunit:
Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.
Subcellular Location:
Nucleus. Cytoplasm. Expressed at lower levels in the cytoplasm.
Tissue Specificity:
Highly expressed in both adult and fetal heart.
Post-translational modifications:
Autophosphorylated.
Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 10 ANK repeats.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 51086 Human
Entrez Gene: 435766 Mouse
Entrez Gene: 295531 Rat
SwissProt: Q59H18 Human
SwissProt: Q5GIG6 Mouse
SwissProt: Q7TQP6 Rat
Unigene: 729320 Human
Unigene: 210428 Mouse
Unigene: 3434 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.