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货号： bs-11111R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11111R-AF350
- 英文名称
- Anti-PCDH1/AF350
- 中文名称
- AF350标记的原钙粘附蛋白1抗体
- 别 名
- Cadherin like 1; Cadherin like protein 1; PC 42; PC42; PCDH 1; PCDH-1; PCDH 42; PCDH42; Protocadherin 1; Protocadherin 42; Protocadherin1; Protocadherin42.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 110kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PCDH1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Protocadherins are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-to-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH1 is a 1,026 amino acid single-pass type I membrane protein that contains seven cadherin domains and is a member of the protocadherin family. Localized to cell-cell and cell-matrix boundaries and expressed at high levels in brain and neuro-glial cells, PCDH1 is thought to be involved in cell adhesion and cell-cell interactions and may play a role in neuronal development. PCDH1 contains a C-terminal cytoplasmic region, an extracellular region and a transmembrane region, and is expressed as two isoforms due to alternative splicing events.
Function:
PCDH1 (Protocadherin 1) belongs to the protocadherin family, a subfamily of the cadherin superfamily. It is a membrane protein found at cell-cell boundaries suggesting a role in cell-cell interaction processes. It is involved in neural cell adhesion, suggesting a possible role in neuronal development.
Subcellular Location:
Cell junction. Cell membrane. Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity:
Highly expressed in the brain and neuro-glial cells.
Similarity:
Contains 7 cadherin domains.
Database links:Entrez Gene: 5097 Human
Omim: 603626 Human
SwissProt: Q08174 Human
Unigene: 79769 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.