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货号： bs-11248R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11248R-AF350
- 英文名称
- Anti-GRAF/AF350
- 中文名称
- AF350标记的Rho GTP酶激活蛋白26抗体
- 别 名
- arhgap 26; ARHGAP26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like protein; OPHN1L; OPHN1L1; RHG26_HUMAN; Rho GTPase activating protein 26; Rho GTPase activating protein26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 神经生物学 信号转导 细胞骨架 细胞外基质 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 92kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GRAF1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases.
Function:
GTPase-activating protein for RHOA and CDC42.
Subunit:
Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.
Subcellular Location:
Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
DISEASE:
Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
Similarity:
Contains 1 PH domain.Contains 1 Rho-GAP domain.Contains 1 SH3 domain.
Database links:Entrez Gene: 23092Human
Entrez Gene: 71302Mouse
Entrez Gene: 307459Rat
Omim: 605370Human
SwissProt: Q9UNA1Human
SwissProt: Q6ZQ82Mouse
Unigene: 654668Human
Unigene: 329396Mouse
Unigene: 214162Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.