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货号： bs-11637R-AF350 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11637R-AF350
- 英文名称
- Anti-APBB3/AF350
- 中文名称
- AF350标记的铁蛋白Fe65样蛋白2抗体
- 别 名
- FE65L2; Amyloid beta A4 precursor protein binding family B member 3; Amyloid beta A4 precursor protein-binding family B member 3; amyloid beta precursor protein binding family B member 3; amyloid precursor interacting protein; Apbb3; APBB3_HUMAN; Fe65 like protein 2; FE65L2; Protein Fe65-like 2; SRA.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human APBB3/FE65L2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimers disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Function:
May modulate the internalization of beta-amyloid precursor protein.
Subunit:
Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins.
Tissue Specificity:
Expressed in various tissues.
Similarity:
Contains 2 PID domains.
Contains 1 WW domain.
Database links:Entrez Gene: 10307Human
Entrez Gene: 225372Mouse
Entrez Gene: 117026Rat
Omim: 602711Human
SwissProt: O95704Human
SwissProt: Q8R1C9Mouse
SwissProt: O35827Rat
Unigene: 529449Human
Unigene: 89673Mouse
Unigene: 30067Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.