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货号： bs-12895R-APC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12895R-APC
- 英文名称
- Anti-TAF11/APC
- 中文名称
- APC标记的转录起始因子TFIID亚基11抗体
- 别 名
- MGC:15243; p30 beta; PRO2134; TAF; TAF(II)28; TAF11; TAF11 RNA polymerase II TATA box binding protein (TBP) associated factor 28 kD; TAF11_HUMAN; TAF2I; TAFII 28; TAFII-28; TAFII28; TFIID subunit p30 beta; TFIID subunit p30-beta; Transcription initiation factor TFIID 28 kDa subunit; Transcription initiation factor TFIID subunit 11.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TAF11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Function:
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the TAF11 family.
Database links:Entrez Gene: 507047Cow
Entrez Gene: 6882Human
Entrez Gene: 309638Rat
Omim: 600772Human
SwissProt: Q15544Human
SwissProt: Q5U1X0Rat
Unigene: 112444Human
Unigene: 11920Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.