产品中心
当前位置：首页>产品中心Anti-PPME1/APC
货号： bs-19988R-APC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19988R-APC
- 英文名称
- Anti-PPME1/APC
- 中文名称
- APC标记的蛋白磷酸酶PPME1抗体
- 别 名
- PME 1; PME-1; PME1; PPME1; PPME1_HUMAN; Protein phosphatase methylesterase 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 42kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PPME1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro).
Subunit:
Binds PPP2CA and PPP2CB.
Post-translational modifications:
Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.
Similarity:
Belongs to the AB hydrolase superfamily.
Database links:Entrez Gene: 535390Cow
Entrez Gene: 51400Human
Entrez Gene: 72590Mouse
Entrez Gene: 361613Rat
Omim: 611117Human
SwissProt: Q58DN4Cow
SwissProt: Q9Y570Human
SwissProt: Q8BVQ5Mouse
SwissProt: Q4FZT2Rat
Unigene: 503251Human
Unigene: 177502Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.