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货号： bs-19580R-APC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19580R-APC
- 英文名称
- Anti-PSTPIP2/APC
- 中文名称
- APC标记的脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体
- 别 名
- Macrophage actin associated tyrosine phosphorylated protein; Macrophage actin-associated tyrosine-phosphorylated protein; MAYP; PPIP2_HUMAN; Proline serine threonine phosphatase interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 结合蛋白 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PSTPIP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Subunit:
Homodimer (PubMed:19584923). Homotrimer PubMed:17964261). Interacts (via coiled-coil domain) with CD2AP, PTPN12 and PTPN18. Interacts (via SH3 domain) with ABL1 and WAS. Interacts (via SH3 and coiled-coil domains) with MEFV (via B-box zinc finger); the interaction allows binding of MEFV to PYCARD and facilitates formation of PYCARD pyroptosomes. Interacts with CD2, DNM2 and FASLG.
Subcellular Location:
Cell Membrane; peripheral membrane protein and Cytoplasmic (by similarity).
Tissue Specificity:
Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta.
Post-translational modifications:
Dephosphorylated on Tyr-345 by PTPN18, this event negatively regulates the association of PSTPIP1 with SH2 domain-containing proteins as tyrosine kinase. Phosphorylation of Tyr-345 is probably required for subsequent phosphorylation at other tyrosine residues. Phosphorylation is induced by activation of the EGFR and PDGFR in a ABL1 dependent manner. The phosphorylation regulates the interaction with WAS and with MEFV (By similarity).
DISEASE:
PAPA syndrome (PAPAS) [MIM:604416]: Characterized by autosomal dominant inheritance of early-onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction.
Similarity:
Contains 1 F-BAR domain.
Contains 1 SH3 domain.
Database links:Entrez Gene: 9050Human
Entrez Gene: 19201Mouse
Entrez Gene: 307248Rat
SwissProt: Q9H939Human
SwissProt: Q99M15Mouse
Unigene: 567384Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.