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货号： bs-13842R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13842R-PE-Cy7
- 英文名称
- Anti-Centaurin beta 2/PE-Cy7
- 中文名称
- PE-Cy7标记的CENTB2蛋白抗体
- 别 名
- ACAP 2; ACAP2; ACAP2_HUMAN; ANK repeat and PH domain-containing protein 2; Ankyrin repeat; Arf GAP with coiled coil ANK repeat and PH domains 2; ARF GAP with coiled coil; Arf-GAP with coiled-coil; CENT B 2; Centaurin beta2; Centaurin-beta-2; CENTB 2; CENTB2; Cnt b2; Cnt-b2; Cntb2; KIAA0041; Pleckstrin homology domains 2; Similar to yeast ZINC FINGER PROTEIN GCS1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞粘附分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 88kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Centaurin beta 2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins mainly regulate membrane traffic. ACAP2 is a member of the centaurin GTPase-activating protein (GAP) family, which comprises a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. ACAP1 and ACAP2 are both widely expressed in peripheral, tubular membranes and usually interact with each other in various tissues. GAP activity of both ACAP1 and ACAP2 is dependent upon phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]. ACAP2 associates with ARF1 and ARF6. Overexpression of ACAP2 blocks the formation of ARF6-dependent protrusions. K1L is a protein required for growth of the Vaccinia Virus that interacts with the ankyrin repeats of ACAP2.
Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
Tissue Specificity:
Widely expressed. Highest level in lung.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.
Contains 1 BAR domain.
Contains 1 PH domain.
Database links:Entrez Gene: 23527Human
Entrez Gene: 78618Mouse
Entrez Gene: 619382Rat
GenBank: NM_030138Mouse
GenBank: NM_001034006Rat
Omim: 607766Human
SwissProt: Q15057Human
SwissProt: Q3UHL4Mouse
SwissProt: Q6ZQK5Mouse
SwissProt: Q5FVC7Rat
Unigene: 478746Human
Unigene: 593373Human
Unigene: 274646Mouse
Unigene: 208307Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.