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货号： bs-13770R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13770R-PE-Cy7
- 英文名称
- Anti-TWEAK/PE-Cy7
- 中文名称
- PE-Cy7标记的肿瘤坏死因子配体超家族成员12抗体
- 别 名
- CD 255; CD255; APO 3 ligand; APO 3L; APO3 ligand; APO3/DR3 ligand; APO3L; DR3LG; MGC129581; MGC20669; secreted form; TNF related weak inducer of apoptosis; TNF-related weak inducer of apoptosis; TNF12_HUMAN; TNFRS12a; TNFSF 12; TNFSF12; TNFSF12 protein; Tumor necrosis factor (ligand) superfamily member 12; Tumor necrosis factor ligand superfamily member 12; Tumor necrosis factor superfamily member 12; TWEAK; UNQ181/PRO207.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 37kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TWEAK/CD255
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Proteins belonging to the tumor necrosis factor (TNF) superfamily are potent mediators of inflammation and of the immune system. Members of the TNF superfamily include TNFβ, lymphotoxin β (LTb), CD154 (CD40L), CD30L, CD27L, OX40L, 4-1BBL, FAS-L (APO-1) and TRAIL. Most TNF family members are type II transmembrane proteins that are proteolytically processed at their carboxy terminal extracellular domain to form a soluble homotrimeric molecule. TWEAK (also designated Apo-3L) has been identified as a secreted ligand belonging to the TNF superfamily. TWEAK seems to induce apoptosis weakly, and it may be involved in cell differentiation in vivo.
Function:
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
Subunit:
Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.
Subcellular Location:
Secreted and Cell membrane.
Tissue Specificity:
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing.
Similarity:
Belongs to the tumor necrosis factor family.
Database links:Entrez Gene: 8742Human
Entrez Gene: 21944Mouse
Entrez Gene: 360548Rat
Omim: 602695Human
SwissProt: O43508Human
SwissProt: O54907Mouse
Unigene: 54673Human
Unigene: 8983Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.